Download the Sponsor/Exhibitor opportunities HERE
Download the Sponsor/Exhibitor opportunities HERE
Pierre-Mehdi Hammoudi
17 rue Crépet
69007 Lyon
+33 (0)4 78 02 39 89
pierre-mehdi.hammoudi@mabdesign.fr
www.mabdesign.fr
BIOPC2024
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Sanofi is a global life sciences company committed to improving access to healthcare and supporting the people we serve throughout the continuum of care. From prevention to treatment, Sanofi transforms scientifi c innovation into healthcare solutions, in human vaccines, rare diseases, multiple sclerosis, oncology, immunology, infectious diseases, diabetes and cardiovascular solutions and consumer healthcare. More than 100,000 people at Sanofi are dedicated to make a diff erence on patients’ daily life, wherever they live and enable them to enjoy a healthier life.
With a rich heritage dating back hundreds of years, Cytiva brings a wealth of technical expertise and talent, a broad and deep portfolio, and exceptional service help researchers and biopharma advance therapeutics at every stage from discovery to delivery.
We supply the tools and support our customers need to work better, faster, and safer, leading to the delivery of transformative medicines to patients. Our combined portfolio includes well-recognized names such as Allegro™, Supor™, iCELLis™, and Kleenpak™, in addition to ÄKTA™, Amersham™, Biacore™, FlexFactory™, HyClone™, MabSelect™, Sefia™, Whatman™, and Xcellerex™.
SGS’s global network of analytical testing, formulation, clinical research, and clinical manufacturing solutions offer a wide range of integrated services and expertise across America, Europe, and Asia-Pacific. SGS experts are ready to support customers throughout the development and commercial manufacture of their drug products, helping ensure the delivery of safe, effective, and compliant medicines to global markets.
www.sgs.com/en/our-services/health-and-nutrition/health-science
With a storage capacity of more than 20 million biological samples, the BioKryo network operates in three European countries, with four dedicated sites. Each site offers a complete range of cryogenic services, including storage temperatures from -196°C to +20°C with all associated services including cryogenic sample transport. This service is destined for research teams in the human and veterinary health sector, pharmaceutical or cosmetic industries, wishing to secure their samples, duplicate their collections or free up space in their premises. Within the BioKryo network, all processes and quality systems are harmonized to meet the highest quality and safety standards for diagnostic, research and therapeutic purposes, wherever a sample is stored. Sample monitoring and traceability is ensured 24/7/365 in a doubled and automatic control by teams of technicians and biologists. All sites comply with Good Manufacturing Practices (GMP) for the reception, storage and provision of biological samples.
DEV’UP Centre-Val de Loire is the economic development agency located south of Paris. It is France’s 1st region in terms of specialization and attractiveness in the healthcare sector.
We coordinate investment projects and partnerships (companies, laboratories, technical centers, etc.) across the healthcare sector. We recently welcomed the largest French industrial investment in the sector ($2.1 billion) by Novo Nordisk and work closely with the global Business France network to support inward and french investment projects and investors who choose our region.
Immerscio.bio is an immersive and tailor-made training platform in Bioproduction.
Occitanie Innovation Biotherapy is a collaborative strategy centred on the biotherapy and bioproduction economic sectors. The Occitanie Region has a robust industrial and academic ecosystem focusing on biotherapy research and medicine. Toulouse and Montpellier exhibit strong synergy in this field.
Various stakeholders, including academic and clinical research centres, industries, and research organisations, represent these technologies.
www.agence-adocc.com/biotherapy-innovation-occitanie/
Contacts:
Bérénice Chaillou (Toulouse): berenice.chaillou@agence-adocc.com
Marjorie Monleau (Montpellier): marjorie.monleau@agence-adocc.com
SANI Membranes is Danish cleantech company, and the inventor of the Vibro® technology. The Vibro® technology is used in biopharma, ingredients, food and dairy industries for filtration, separation, clarification and concentration. Primary applications are processing of all kinds of cell cultures, proteins, enzymes and separation of target molecules.
European leader in analytical sciences
Quality Assistance centralises all services on one site in Thuin, Belgium.
Are you tired of wasting time, money and energy with multiple scattered contract laboratories?
Our experts are here to help you speed up the development and marketing of your innovative pharmaceutical products. We design customised solutions, define analytical protocols, and develop and validate specific new analytical methods for each client project. Our full range of services are fully compliant with EMA and FDA regulations.
PathoQuest is a global CRO providing Next Generation Sequencing (NGS)-based Quality Control testing through its iDTECT® assay platform. This platform enables faster, safer and animal free testing for the release of biotherapies to patients. We offer GMP-validated assays for viral safety and genetic characterization of raw materials, cell and gene therapies, monoclonal antibodies and vaccines. Our laboratories in Paris, France, and Wayne, PA, USA, provide global and reliable support to accelerate the availability of biologics.
Croda develops and supplies high purity pharmaceutical excipients to enhance delivery, efficacy, and stability of actives as well as highly performing vaccine adjuvants and in-house formulation expertise to aid in navigating drug and vaccine formulation challenges. Moreover, our bioprocess portfolio brings new generation excipients to meet the biopharma requirements in this field.
With a product profile proven to stabilise, solubilise and to deliver the most challenging of active pharmaceutical ingredients and a substantial investment in GMP and multi-site EXCiPACT accreditation, Croda demonstrates confidence in both excipient quality and supply chain security.
Repligen is a bioprocessing-focused life sciences company bringing expertise and innovation to our customers since 1981. We are inspiring advances in bioprocessing through the development and commercialization of high-value products and flexible solutions that address critical steps in the production of biologic drugs.
Sensor Systems for Bioprocess Monitoring
Hamilton process sensors are well known for high quality, long life, unique features, and competitive pricing. In order to meet these rigorous requirements, we are constantly striving to find new ways to design our sensors. As a result of the extensive work by our research and development department, Hamilton is able to offer outstanding solutions for pH, dissolved oxygen, dissolved carbon dioxide, cell density, conductivity and ORP monitoring.
Waters Corporation is a global leader in analytical instruments and software, providing innovative solutions for biopharma organizations. Our cutting-edge technologies enhance process efficiency, ensure product quality, and accelerate drug development, enabling our clients to deliver life-saving therapies faster and more effectively. Empowering biopharma organizations and scientists in labs around the world, we deliver scientific insights that unlock the potential of science, to solve problems that matter.
Promepla – Your innovation booster for single-use solutions.
From design and development up to the manufacturing and sterilization, Promepla is your one-stop-shop partner to move forward with.
Promepla brings its support from early stages of design and development of single-use biopharm solutions, providing high-end overall service.
Injection molding, customized single-use components and assemblies, clean room manufacturing, QA/RA support : our experts are present with you to enhance your experience.
Partnership, flexibility and agility: the key-words for your partnership with Promepla.
At Venair, we design and create fluid transfer solutions that help top leading companies run all their operations with precision and reliability.
Today, we present more than 35 years of experience manufacturing custom high-quality products and delivering direct assistance to the most demanding industries across the world.
Together, we will achieve the maximum operability for your critical applications.
Quantoom Biosciences is leading the revolution in mRNA-based vaccines and therapeutics by offering turnkey solutions for mRNA-LNP manufacturing. Its cutting-edge Ntensify™ technology enables the production and purification of mRNA through a fully integrated, scalable system that combines processes, equipment, reagent mixes, and disposables. This solution supports the entire spectrum of mRNA production, from R&D to commercial manufacturing. Launched in 2023, Ntensify™ has already been widely adopted across multiple continents, showcasing its global appeal. Quantoom Biosciences is also developing the Ncapsulate™ technology for mRNA-LNP formulation and purification, aiming to significantly increase the accessibility and affordability of mRNA-based drugs. Located in Belgium, Quantoom Biosciences thrives in a dynamic biotech ecosystem, driving innovation in mRNA production to make life-changing therapies available to everyone, everywhere.
Getinge is a global provider of innovative solutions for the life sciences industry. Thanks to our unique expertise, we offer equipment (washers, sterilizers, autoclaves, isolators and bioreactors) and sterile transfer solutions mainly for pharmaceutical production, including laboratory applications, but also for other industrial and research applications. Since the acquisition of Applikon Biotechnology in January 2019, a specialist in the manufacture of bioreactors and fermenters, Getinge offers a complete range of systems for optimizing your bioprocesses.
Step into the future of fluid management tubing with RAUMEDIC. Backed by 70+ years of experience in processing polymer tubing, RAUMEDIC serves Pharma and Biopharma with first-class single-use tubing that exceeds expectations. Discover unique and patented innovations, such as our Low-Tack treated silicone tubing, and benefit from fewer impurities and enhanced pumping properties. Need a specific solution? As a single-source supplier, RAUMEDIC stands ready to serve your fluid processing needs.
Greiner Bio-One is a member of Greiner AG. Founded in 1868, Greiner AG is a family-owned German company specializing in techno-polymers. Greiner Bio-One is an international medical technology company, present in over 100 countries. The BioScience division has become one of the world’s leading technology partners for universities, research institutes, the pharmaceutical and biotech industries.
Promega is a worldwide leader in biochemistry, cellular and molecular biology with the development of innovative technologies for the Life Sciences.
Based on bioluminescent technology innovations, Promega offers a broad portfolio of functional reporter bioassays, primary cell killing assays and immunoassays, used for R&D or QC batch release of therapeutic antibodies and cell/gene therapies.
With their new bioassay development and qualification services, Promega can help accelerate your biologics drug discovery and development workflow.
france.promega.com/applications/biologics-drug-discovery/functional-bioassays/
RD-Biotech is a French CRO / CDMO providing tailor-made development and production services, for Research to clinical applications.
– From DNA vector cloning to plasmid DNA production – scalable process from R&D to GMP grades
– From mAb production to antibody sequencing and recombinant antibody development
– From pilot up to large-scale batches (up to several grams)
– And expression of recombinant proteins in multiple systems.
Genovis offers SmartEnzymes™, a unique selection of rapid and easy-to-use enzymatic tools designed to improve the efficacy and throughput in analytical or preparative workflows for complex biopharmaceuticals. Available worldwide, the enzymes are supplied in innovative formats for the characterization, development, production and quality control of e.g. monoclonal antibodies, antibody-drug conjugates, biosimilars and bispecifics. The applications of SmartEnzymes include antibody digestion, antibody deglycosylation, antibody conjugation, antibody glycan remodeling, N- and O-glycan profiling, affinity purification and proteomics.
METTLER TOLEDO, spécialiste des mesures industrielles, offre des instruments et des services de précision pour de nombreuses applications dans la recherche et le développement, le contrôle qualité, la production, la logistique et le commerce à des clients dans le monde entier.
At Tebubio we facilitate Life Sciences Research everyday. Through our local offices located across Europe, we support Life Sciences and Biotechnology Researchers with a unique, holistic range of solutions to advance their projects faster thanks to:
· Easy access to cutting-edge biological solutions.
· Our Contract Research Services laboratory
· Simplified ordering process.
With Tebubio, accelerate what’s most important to you: Your Research.
Since 1975, Agro-Bio provides Antibody services for life sciences industries. We generate your customized anti-idiotype and anti-drug monoclonal or polyclonal antibodies (for Pk, immunogenicity, receptor occupancy…). We monitor and quantify the HCP in your bioproduction system with the coverage 2D, we develop our specific anti-HCP antibodies and HCP ELISA kits. We analyze the binding capacities of your antibodies against a target (affinity and kinetics), determine and monitor your critical quality attributes (CQA: active concentration, Fc receptor binding…) on our Biacore platform.
Etablissement Français du Sang (EFS) is offering a full range of services to make ATMPs accessible to patients for highly unmet medical needs.
Based on our 4 pharmaceutical ATMPs production platforms all over France, EFS is equipped with 16 GMP class B-rooms.
EFS expertise provides you with a real support on development stages, scaling up and GMP manufacturing for your preclinical and clinical batches. EFS helps yourselves on a multiple cells types such as MSC, CAR-T, iPS, hESC and HSC.
Looking forward to meeting you in Tours!
Our full-service logistics and storage solutions help you seamlessly deliver innovation.
We manage the logistics for your most precious innovations. And we don’t take that responsibility lightly. Across our global network of dedicated team members, we monitor the safety and integrity of your product proactively, ensuring it reaches patients without delay. We plan for contingencies, so you don’t have to, leveraging our global capabilities and local, on-the-ground knowledge to navigate logistics complexities. Our innovative distribution services for medications, including rare, orphan, and gene therapies, are customized and scalable to fit your product’s needs.
We go the extra mile to ensure increased supply chain afficiency, maximum return on investment, and enhanced patient care.
Verdot, established in 1950 and headquartered in Riom, France, stands at the forefront of downstream bioprocessing technology. Verdot focuses on innovative purification solutions for the biopharmaceutical industry, including chromatography columns, and custom and standardized chromatography and tangential flow filtration (TFF) systems.
Verdot serves a diverse customer base, including research and development, early-stage biotech, biopharma, and CDMOs in all stages of the drug development workflow from exploration through to manufacturing of commercially available biologics.
Bio-Techne is a global developer, manufacturer and supplier of high-quality reagents, analytical instruments, and precision diagnostics. Whether you’re at the cutting edge of academic research, translating basic discoveries to therapeutic leads, or at a facility that requires the highest level of diagnostic testing, our award-winning tools and solutions empower scientists and clinicians to achieve reproducible and consistent results. Trusting Bio-Techne means choosing confidence that every solution you use will help move you toward better answers.
Based on a disruptive stirring principle, Cellura has developed a new kind of scalable low shear bioreactor with efficient resuspension capacitie.
Our mission is to empower the bioproduction of shear-stress sensitive cells (i.e. : stem cells) that are of major interest for healthcare and agri-food markets.
With our first version of our bioreactors, the SoftXSTM, you can unlock your process of production and going further into your development.
In the realm of biopharmaceutical production, Chinese Hamster Ovary (CHO) cells have emerged as the main expression system for recombinant therapeutic proteins (RTPs), despite the availability of several alternative cell lines. CHO cells are among the most widely used worldwide for their unique advantages, e.g, the variety of post-translational modifications that closely mimic those found on human cells (Stach et al. 2019); their high degree of biosafety due to their low risk of propagation of human viruses infection (Lalonde and Durocher, 2017); their adaptability from adherent to suspension cell culture in serum-free media (Davami et al. 2014). Thanks to these combined attributes that solidified the position of CHO cells, they have become the gold-standard of the bioindustry and are responsible for the production of approximately 70% of all marketed RTPs (Pereira et al., 2018; Stolfa et al., 2018; Dziomba et al. 2023).
Fetal bovine serum (FBS) is commonly used as a supplement to basal media for in vitro cell cultures (including mammalian, animal, insect, and bacterial cells). Many studies have revealed its rich composition, containing essential macro- and micronutrients such as growth factors, adherent factors, amino acids, hormones, and vitamins (Michael Butler et al. 2020), which are crucial for proper cell function. In addition to the ethical issue, increasing demand, high cost, significant contamination risks (bacterial and viral), and batch-to-batch variability of FBS prompt us to seek alternatives. To reduce or eliminate FBS use, we have decided to implement culture media with various plant protein hydrolysates. Although serum-free media have been available for several decades, and their widespread adoption has increased, despite the fact that their compositions are undefined for users. Our goal is to make these serum-free media more accessible considering that serum-free media cost about 1.5 to 3 times more than serum-containing media.
Several publications highlighted the effects of vegetable proteins hydrolysate (peptones) as supplements in basal media, i.e : the enhancing of the cell growth and productivity of recombinant proteins (Burteau et al. 2003; Michael J. Betenbaugh et al. 2020). Some publications have shown an enhancing of the volumetric productivity more than 100%, and a 40% increase in cell number (Davami et al. 2014; Davami et al. 2015). Then, the composition of these plant hydrolysates varies according to the plant source and the production process. Thanks to their vegetable origins there are neither ethical issues, nor health standards.
In the present study, the effect of different peptone concentrations on the CHO-K1 cell line under various culture conditions (adherent/suspension) in a basal medium with a 10-fold reduction of FBS have been evaluated. Supplementation with wheat peptones at defined concentrations increased the viable cell density of CHO-K1 in adherent conditions by 190 – 265%.
Additionally, the suspension culture exhibited different results compared to the adherent conditions. In suspension cell culture, only three peptones – wheat, soy, and pea – enhanced viable cell density compared to the medium without hydrolysates. Actually, the only peptone supplementation is not enough to be completely serum-free, but that can reduce the FBS consumption.
Fabien Compeau is a researcher at both Organotechnie and Université Sorbonne Paris Nord, within the Tissue Engineering Research Unit. With a solid foundation in molecular and cellular biology. His current work centers on developing serum-free media. He completed three years of study at CY Cergy Paris Université and two years at Université Paris Cité. His internships provided valuable experience at the Institut de Recherche Criminelle de la Gendarmerie Nationale, the Institut Jacques Monod, and the Institut Pasteur, his research
focused on cell signaling, dynamics, and differentiation.
Process analytical technology (PAT) aims at real-time, sampling-free monitoring of bioprocesses, for instance at the upstream stage (USP), when suspensions of CHO (chinese hamster ovary) cells grow in bioreactors and produce monoclonal antibodies (mAbs). The advantages of in-line PAT over the off-line approaches are numerous, from scientific, economic and ecological points of view. Using light as a non-invasive PAT tool is one of the promising ideas that give rise to various technological solutions. Nevertheless, the implementation of novel PAT approaches is limited and still requires further progress in analytical instrumentation and its integration in the whole process.
In this talk, we plan to present a short overview of advances in implementation of molecular optical spectroscopy as a PAT tool in upstream processing of therapeutic antibodies we obtained in the framework of our interdisciplinary research project CLIMB’IN. The project uses analytical spectroscopy based on light absorption and/or multi-angle scattering, both elastic (Rayleigh) and inelastic (Raman) for quantitative monitoring of multiple critical process parameters (CPPs). The advances reached by the CLIMB’IN consortium involve instrumental design and experimental protocols, with a particular focus made on machine learning algorithms. Brought together, these advances allow to improve the relevance and the robustness of the corresponding PAT approaches required for their industrial implementation.
Today, virus-based products like oncolytic viruses and gene therapies are part of the most promising biotherapies. The development of biomanufacturing processes for viral products is not a straight road. It is generally associated with process complexity and biological variability. In depth expression system characterization by adding biological data to standard chemical data will help to understand bioprocesses. With a close collaboration between Naobios and Gensensor, case study from Vero cell substrate-based process will illustrate how transcriptomic data may help to understand and monitor biological variability linked to bioprocesses.
Anne-Sophie has a PhD in cell biology and is engineer in biotechnology. After working on cell stress and death pathways, Anne-Sophie specialized in the development of advanced therapy medicinal product. Now Principal Scientist at GenSensor, she is in charge of identifying biomarker panels on different expression systems and leads, with her team, the company’s internal research projects and scientific collaborations.